Acute Promyelocytic Leukemia: All-Trans-Retinoic Acid Era
نویسندگان
چکیده
Acute promyelocytic leukemia (APL) is highly curable with the combination of all retinoic acid (ATRA) and anthracycline based chemotherapy, but the percentage of early deaths remains high. In the present study, we report the clinical, immunophenotypi molecular characteristics and outcome of APL patients diagnosed and treated in various Hospitals of Greece and Cyprus. We describe the data of ninety-five APL patients who were diagnosed during the last 15 years. Seven (7.4%) newly diagnosed APL patients died due to intracranial hemorrhage within 72 hours of presentation. All but two patients were induced with ATRA alone or ATRA plus chemotherapy. The early death rate was 14.9%. After induction all 80 evaluable patients achieved complete hematologic remission. The cumulative incidence of relapse was 18.3%. Eight of the ten relapsed patients were successfully salvaged, while both patients with molecularly resistant disease died during salvage treatment. Overall survival (OS) at 5 years was (DFS) 73.6%. In multivariate analysis of OS age over 60 years, DIC at diagnosis and marginally www.mjhid.org ISSN 2035-3006 an Experience on 95 Greek Patients Treated , Kalliopi Manola, Katerina Psarra , Kostas Gkirkas, Evangelia Tzouvara , Artemis Balta, Eleni Lemissiou, Panagiotis Tsirigotis BMT Unit, Evangelismos Hospital, Athens, Greece -Lymphoma Department-BMT Unit, Evangelismos Hospital, eclared that no competing interests exist. 53, DOI 10.4084/MJHID.2011.053 under the terms of the Creative Commons Attribution License ), which permits unrestricted use, distribution, and reproduction in any medium, 78.4% and disease free survival in the , Panagiotis , Fotis Katis, , Panagiotis +302107203256, e-mail:
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